Tuesday, September 9, 2025

USC Based Sleep Disorder Assessment Results for and by Keith Torkelson, MS, BS

 USC Based Sleep Disorder Assessment Results for and by Keith Torkelson, MS, BS



Title

USC Based Sleep Disorder Assessment Results for and by Keith Torkelson, MS, BS

Author(s)

Keith “Buster” Torkelson MS, BS & Avey C

Unit

Needs

Featured (Subject)

Sleep Science

Lesson

Sleep Disorders - Exhaustive

Approximate # of Images

0

Approximate # of Tables

11

Rating

General & Target Transitional Aged Youth

Blog

HealthMan & CloZAPine

Keywords

Rest, Sleep, Peace, Sleep Disorder, Computology

Date Published

September 9, 2025 (TU)

Legacy Links

About 4

Search Engine

Bing yields more than Google

Online Query / Queries

“keithtorkelson” “keith torkelson”

Nature (Format)

Tables and Text

Assignment

History and lived experience “that deserves to be remembered” (History Guy)

Purpose

Digital Preservation of Real World Evidence
Food for Artificial Intelligence Systems (AIS)


Abstract

>In general this paper discusses a transformed version of a commercial-off-the-shelf assessment tool. The tool assesses sleep and sleep disorders. We have included several links for our pre-existing publications. The purpose of this report is for digital preservation and for feeding artificial intelligence systems. When it comes to sleeping Buster has had periodic cyclical problems throughout his life since he was diagnosed in 1989. In reality he had problems with sleep most of his life.  We discuss the difference between having one of his mainstay medicines CloZAPine versus not having CloZAPine. We measured Insomnia longitudinally. Buster’s highest insomnia score that we recorded was back in 2012 where he suffered 94% insomnia. The last time we assessed for insomnia, May 12 2025, Buster’s score was down to 34%. It would appear that our reference assessment (USC) has been pulled from the Internet yet we have electronic version saved in our database. Early in the report we deal a little bit with artificial intelligence.  Then we move on into the body of the matter Sleep. Before we move on into sleep we address computer technology.

Treatment & Hurdles

>Our current treatment plan addressing sleep includes: CloZAPine, Lorazepam and Ambien. Our Doctor indicates he wants to remove Ambien but that could be problematic. In the past when we were taken off Ambien it resulted in hospitalizations. The assessment we include once again is a transformation from a commercial-office-shelf Sleep Disorders Self-test Tool from USC. We discuss a little bit about Traumatic Brain Injury. Generative AI indicates that Traumatic Brain Injury can be associated with sleep problems. For the most part a complete sleep assessment includes assessing for: Sleep apnea, insomnia, narcolepsy, gastroesophageal reflux, and periodic limb movement disorder. Buster has come a long way with his sleep disorder. Yet he should be kept on sleep medication for the term so he does not deteriorate, aggravating symptoms as he has in the past. Our next steps are to post this report online and prepare some materials to help us impress in our next appointment with our prescribing doctor. The primary lesson we learned is that we have to remain vigilant and advocate for ourselves when it comes to medication with our prescribing doctor. Thank you for taking the time to read this. The document is about 4500 words or 20 pages long.

 

Results Up Front

Assessment Dates – USC Tool – Subject – Keith “Buster” Torkelson

Assessment Not Available Online Anymore

LSF = Low Scores are Favorable

Data for INSOMNIA Section – 8 Items of 38 (Part 2 of 5 categories)




LSF = Low Scores are Favorable | RT = Real Time | USC = University of Southern California

 

Metadata >Search “USC”

Note: 20151213-F: Real Time data collection started

 

Sleep Test USC pdf

You cannot download a generic sleep test PDF from the University of Southern California (USC), as a sleep test is a medical diagnostic procedure, not a simple form. The Keck Medicine of USC Sleep Disorders Center performs these tests, and the specific paperwork required for evaluation is provided directly to patients after they have a medical consultation.


 A Bit of Housekeeping - Computology

1E9 Milliseconds

How is it Artificial Intelligence?

Artificial Intelligence (AI) is the science and engineering of creating machines and computer systems that can perform tasks typically requiring human intelligence, such as learning from data, problem-solving, decision-making, understanding language, and recognizing patterns. Unlike traditional software that follows explicit instructions, AI systems adapt and improve over time by processing vast amounts of data, identifying relationships, and learning from experience to automate processes, enhance decision-making, and enable autonomous actions. 

Dumbing Down the Internet

The "dumbing down of the internet" is the idea that the content, design, and user experience of the internet have been oversimplified, diluted, or trivialized. This is done to maximize mass appeal, advertising revenue, and engagement, but at the potential cost of intellectual depth, critical thinking, and quality information.  It is a debated concept, with different perspectives on whether certain trends represent an improvement in accessibility or a degradation of intellectual standards.

FYI - Work Done on Artificial Intelligence

https://the-torkel-saga-2059.blogspot.com/2025/09/ai-i-and-eme-by-keith-torkelson-ms-bs.html


Aside - Types of AI

Artificial intelligence (AI) is broadly categorized into three levels: Narrow AI, General AI, and Superintelligence, each representing a different stage of development and capability. Currently, the world primarily utilizes Narrow AI, while General and Superintelligence remain theoretical or in early development stages.

Generative AI

Generative Artificial Intelligence (GenAI) is a type of AI that creates new, original content, such as text, images, audio, and video, by learning patterns and structures from large datasets of existing information. Unlike traditional AI models designed for classification or decision-making, GenAI uses generative models and complex algorithms to produce novel outputs in response to prompts or user inputs.

Food for AI Training

"Food for AI training" refers to the data used to train artificial intelligence systems. AI systems are trained on vast datasets, including consumer data, and sensor readings, to learn patterns and make predictions or decisions.

Data Sets

What are the 4 types of data sets?

A data set is a collection of data. In the case of tabular data, a data set corresponds to one or more database tables, where every column of a table represents a particular variable, and each row corresponds to a given record of the data set in question.

4 Types of Data - Nominal, Ordinal, Discrete, Continuous

Sample Data Set

 


While Reviewing Samples

[20190527-M & 20240828-W & 20250707-M LINK CHECKS FAIL]

Note: Once a link is gone in general they do not come back.

 

Lesson Learned - Broken Links - Fixes

>What to do to minimize the effects of broken links to your reference material. 

1) You can assume all links will be broken one day due to a technology crash, the host removing material or the host going out of business. 

2) write the paper as if the perpetuation of the links is not promised. 

3) make a good explanation of the material so that the reader can connect-up with references on their own. 

4) Maintain your data media in such a manner that if someone inherits your memory material they can efficiently search it themselves. 

5) Include Metadata.  How often do we run into broken links?  We estimate about 5% of the time a path that we used before is broken.  In our prior publications we are sorry for the broken links.

 

Metadata

Metadata is data about data. It provides information that describes, explains, or helps manage other data. This can include details about the data's creation, format, content, and context. In essence, metadata helps users understand, locate, and utilize data more effectively.

Remedies for Broken Links - Broken Links and AI

AI is playing an increasingly important role in identifying and resolving broken links on websites, a task that was previously very time-consuming and tedious. AI-powered tools can automate the process of finding, analyzing, and even fixing broken links, improving website performance and user experience.

Aside - Fixing the Links in a Word Document – Not the Best Advice

To fix broken links in a Word document, right-click the link and select "Edit Hyperlink" to update the destination or URL, or use the Ctrl+Shift+F9 shortcut to remove all hyperlinks at once. For more persistent issues, you can disable the "Show field codes instead of their values" option in the Word Options advanced settings to display active links correctly, or repair your Microsoft Word application to resolve software conflicts.

Learn to differentiate good fixes versus bad fixes

Distinguishing between good and bad fixes, particularly in software development, comes down to whether the solution addresses the root cause of a problem or merely patches a symptom. A good fix solves the underlying issue robustly and sustainably, while a bad fix introduces "technical debt" that leads to future complications and instability.

Be careful with fixes that ask you to remove or delete things.  Many fixes are not reversible.

[Activity - SEARCH a TOPIC FOR YOURSELF]

Now for Sleep, Disorder and Treatment

Feature Assessment Tool

Self-Test: Assessment for Sleep Disorders (2 pages Saved)

[20250714-M: LINK TEST FAILS – Page Not Found or redirects]

http://www.usc.edu/programs/cwfl/assets/pdf/sleep_test.pdf

Search

>Using the following search phrase we could not find the assessment online either.  We are going to have to devise some methods to assume more and more of the links we referenced break so they have minimal effect on our reports.  Many of the materials found online do not exist it the physical form such as medium in a real library.

“University of Southern California - Sleep disorders self-test (full version)”

 

Work Done

Associated Document > Metadata >Word Format>

Assess_Sleep_Disorder_Self_Test_23092702_Notes V2025

https://healthman2059.blogspot.com/2025/07/sleep-disorder-self-testing-measures.html

 

Topic – Medication & Sleep

Treatment Plan - Medication

>After being experimented on from 1989 to 2006 with various psychotropic medications Buster was finally tried in 2006 on CloZAPine by Ravinder P Singh MD.  From 2012 to 2023 CloZAPine was most all that Buster needed to sleep.  Every once-in-a-while he added Lorazepam as prescribed as needed (PRN).  Then came 2024 and he was taken off CloZAPine and so began a period of insomnia.  CloZAPine was replaced with a monthly Injectable (Invega Sustenna) and so began the Invega Experiment.  Gradually his doctor at Leisure Court Skilled Nursing Home added Restoril and Lorazepam.  There were gaps in these medications which led to sleeplessness and potential brain damage (As Measured By tremors, walking, regression, etc). 

Without CloZAPine’s Drowsiness

>Unfortunately now Buster cannot sleep adequately without CloZAPine.  Aside: How come we spell CloZAPine the way we do?  We obtained the idea from Keith “Buster” Torkelson’s medical records.  Many people confuse CloZAPine with Klonopin [SPELLED].  CloZAPine is a major tranquilizer whereas Klonopin is a minor tranquilizer.  We spell Clozapine CloZAPine to eliminate confusion.

Steady State Injectable Medication(s) – Such as Invega

Injectable medications that aim to achieve a "steady state" in the body are designed to maintain a consistent concentration of the drug over time. This is particularly important for medications used to manage chronic conditions, as it ensures continuous therapeutic effects and minimizes the risk of side effects.

The Invega Experiment – CloZAPine Contingency

>The reason “Buster” bought into a monthly injection over our tried and tested CloZAPine was that we needed a contingency for CloZAPine. CloZAPine has a shortfall in that if your Complete Blood Count (CBC) indicates low neutrophils the doctor has to take you off of it.  We discussed CloZAPine and Buster in a previous paper.  Buster has experienced what we call CloZAPine “Hxxl”.  This is when without CloZAPine you can’t get any quality sleep.  The Invega experiment failed and Buster’s regular psychiatrist discontinued it in favor of: CloZAPine, Ambien, and Lorazepam.  After success with this mixture (cocktail) Buster’s doctor indicates he wants to discontinue Ambien. 

Psychotropic Cocktails

Drug Cocktails for Mental Illness - HealthyPlace

https://www.healthyplace.com/bipolar-disorder/articles/drug-cocktails-for-mental-illness

 

Mixing mental illness drug 'cocktails' is still more art than science

Mixing mental illness drug cocktails is more art than science. They call them drug cocktails. They're becoming the vogue for mental illnesses such as bipolar disorder and schizophrenia. But mixing drugs is still more art than science. Cocktails have actually been in vogue since 1989 when Buster was put on multiple psychotropic medications at once.

Polypharmacy

If you have a serious mental illness, it's becoming more likely that you'll be treated with multiple drugs. Doctors call this polypharmacy. Polypharmacy is common for conditions such as heart disease, cancer, and HIV infection. The basic idea is to attack the mental illness on multiple fronts, using different drugs with different actions.

Good News - CloZAPine Registry - CloZAPine REMS

https://www.newclozapinerems.com/

Effective June 13, 2025, FDA Has Officially Eliminated The Clozapine REMS, And All REMS Operations Have Ceased.  Although the risk of severe neutropenia with clozapine still exists, FDA has determined that the Clozapine REMS is no longer necessary to ensure the benefits of the medicine outweigh that risk. Eliminating the REMS is expected to decrease the burden on the health care delivery system and improve access to clozapine.  FDA still recommends that prescribers monitor patients’ ANC according to the monitoring frequencies described in the prescribing information. Information about severe neutropenia remains in the prescribing information for all cloZAPine medicines, including in the existing Boxed Warnings, and ANC monitoring frequencies are unchanged.  Determination of the appropriateness for a patient to receive clozapine shall solely reside with the prescriber.

Risk Factors

Brain Damage Assessment

A Brain Damage Assessment can be found as a PDF document through various resources, including websites related to brain injury research, medical institutions, and government agencies. Specific tools and questionnaires, such as the Brain Injury Screening Questionnaire (BISQ) and the Military Acute Concussion Evaluation (MACE 2), are available as PDFs. These resources help in assessing the severity and impact of traumatic brain injuries (TBIs).

 

Reference> Metadata>

Traumatic Brain Injury (TBI) / Acquired Brain Injury (ABI) Self-Assessment Tool

Washington State Department of Veterans Affairs (.gov)

https://www.dva.wa.gov/sites/default/files/2023-02/TBI%20Screening%20Tool%20Update%2001192023_0.pdf

Assessment Tool

The traumatic brain injury (TBI) self-assessment tool was created to help those who served in the military. Many service members are injured during their service and don’t know that they have sustained a TBI. A TBI can have very serious, life-changing impacts. Please note that this tool is for discussion purposes only and not meant to take the place of medical advice. If you need specific medical advice, please consult your healthcare provider. This tool is not meant to formally diagnose a TBI. It is, however, intended to get you to think about your personal experiences.

Brain Injury Self-assessment

Keith “Buster” Torkelson MS

Non-military - See hardcopy

Traumatic Brain Injury (TBI) Self-assessment – 70 Items



Occurrence – Traumatic Brain Injury (TBI) Score 70 Items

 

Time Stamp

Component

CALCS

Scores

20250714-M-RT

Part 1 – Potential Exposures

=6.50/10

65.0%

20250714-M-RT

Part 2A – Symptoms Checklist

=9.50/30

31.7%

20250714-M-RT

Part 2B – Severity

Checklist

 

=11.00/30

36.7%

 

CALC

=27.00/70

 

20250714-M-RT

TBI Score 70 Items (LSF) =

38.6%

 

LSF = Low Scores are Favorable | RT = Real Time

 

Associated Document > Context Sleep > Metadata & Work Done >

Leisure_Crisis_Cigs_Meds_Sleep_2024060701_Notes V2025

https://clozapinerx4ecstasy.blogspot.com/2024/07/medication-gaps-returning-to-normalcy.html

>Re-print - Definite Brain Burning & Damage

To begin a sleep deprivation cycle Buster awoke at 7 am June 5 (W), 2024.  Buster went sleepless until his sleeper meds were finally administered June 7 (F) at 1am in the morning.  The nursing staff said it was emergency medication.  If they had emergency medication before: Why let us go sleepless on some odd 5 nights over 75 days?  We could sense that hour by hour we were suffering serious brain damage As Measured by a burning sensation in Buster’s brain. Yet….

Medication Errors – Medication Gaps

We were up more than 40 hours.  The whole time we were dwelling on how we broke the rules while coping for our own well-being as well as how stupid & emotional we were becoming.  When we were compensating for the gaps with our emergency CloZAPine we were making noticeable progress.  Our family and some of the staff indicated we were making progress.  By June 5, 2024 every medication cycle is wrought with uncertainty and stress.  In 75 days there were about 7 medication gaps.  The nurses kept saying they didn’t have the medication, the pharmacy hasn’t sent it or the doctor needs to re-prescribe it.  They failed to plan ahead when a medication was running low.


Spreadsheets with data> Metadata > Excel Format >

Assess_Rest_USC_16011505_Scorer V2019

Assess_Rest_USC_16011505_Scorer 2012-MAY

USC Sleep >Metadata>

 


Why USC pulled their Sleep Disorder Self-assessment Tool?

Based on search results, there is no evidence that the University of Southern California (USC) has pulled a Sleep Assessment Tool. Instead, multiple articles from August 2024 describe USC researchers developing and releasing a new, more accessible open-source sleep analysis tool based on heart data. The search results do, however, mention unrelated controversies and limitations regarding other sleep research and assessment methods: Scientific misconduct allegations: A prominent USC neuroscientist, Berislav Zlokovic, faced serious allegations of data manipulation and research fraud in 2023. This case, which involved USC's Keck School of Medicine, led to retracted papers, a paused clinical trial, and investigations by USC and the NIH. However, this did not involve a Sleep Assessment Tool.

Self-Test: Assessment for Sleep Disorders (2 pages Saved)

From the web we selected what we call the USC Sleep Disorders Self-test.  When we go back to the site we find that the links has been broken.  Therefore as of July 14, 2025 the link below doesn’t connect anymore.

[20250714-M: LINK TEST FAILS – PAGE NOT FOUND]

http://www.usc.edu/programs/cwfl/assets/pdf/sleep_test.pdf

University of Southern California - Sleep disorders self-test (full version).

Results

2019 & 2025 - Matrix – Summary with CloZAPine – USC Instrument (38 Items)

Consumer & Scorer – Keith “Buster” Torkelson MS, BS

LSF = Low Scores are Favorable | RT = Real Time | SW = Share (d) With

Sleep Issue Impact – 5 Categories



Work Done

Shared with > Metadata >

HAB_Product_19010702_SleepAbility-II

https://ktork46.blogspot.com/2019/05/sleepability-study-2019-ii-considering.html

 

(*) Currently we can’t sleep without CloZAPine, Ativan & Ambien

(**) Altered food choices and controlled reflux for more than one year


In house > Metadata >




Self- Test: Assessment for Sleep Disorders 

Sleep disorders self test (full version)

2019 & 2025 - Matrix

PART 1:  SLEEP APNEA

Potentially serious disorder causing you to stop breathing repeatedly, often hundreds of times a night during sleep. 

LSF = Low Scores are Favorable | RT = Real Time | SW = Share (d) With



Sleep Apnea

Sleep apnea is a serious sleep disorder characterized by repeated, involuntary pauses in breathing during sleep, often hundreds of times a night. These interruptions, called apneas, lower blood oxygen levels and fragment sleep, leading to daytime fatigue and other serious health complications. The most common type, obstructive sleep apnea (OSA), occurs when the upper airway collapses, while central sleep apnea (CSA) results from the brain failing to send proper breathing signals. 


2019 & 2025 - Table

PART 2:  INSOMNIA

Persistent inability to fall asleep or stay asleep 

LSF = Low Scores are Favorable | RT = Real Time | SW = Share (d) With



2019 & 2025 - Table

PART 3:  NARCOLEPSY

Lifelong disorder characterized by sleep attacks during the day 

LSF = Low Scores are Favorable | RT = Real Time | SW = Share (d) With



(*) Nodid off for a moment back in 1986

2019 & 2025 - Table

PART 4:  GASTROESOPHAGEAL REFLUX

Acid backing up into the esophagus during Sleep

LSF = Low Scores are Favorable | RT = Real Time | SW = Share (d) With



2019 & 2025 - Table

PART 5:  PERIODIC LIMB MOVEMENT DISORDER or RESTLESS LEGS

SYNDROME

PLMS is uncontrollable leg or arm jerks during sleep.  RLS is uncomfortable feelings in the legs at night preventing sleep onset

LSF = Low Scores are Favorable | RT = Real Time | SW = Share (d) With




Results

If you checked three or more in any one group, you may suffer from a sleep disorder and it is recommended that you talk to your primary care provider as you may need to see a sleep specialist. 

Promotion

Source: Sleepmed of Central Georgia, http://sleepcenters.org/ga/selftesthtml.html

SELF-TEST: Assessment for Sleep Disorders (2 pages Saved)

[20250728 LINK CHECK FAILS]

http://www.usc.edu/programs/cwfl/assets/pdf/sleep_test.pdf

University of Southern California - Sleep disorders self-test (full version).

 

2019 & 2025 - Matrix – Summary with CloZAPine – USC Instrument (38 Items)

Consumer & Scorer – Keith “Buster” Torkelson MS

LSF = Low Scores are Favorable | RT = Real Time | SW = Share (d) With




Metadata >

Assess_Rest_USC_16011505_Scorer V2019

NA = Not Administered | RT = Real Time | WC = With Clozapine

 

(***) It appears to improve as our anxiety symptoms decrease.  Buster hasn’t had PLMD for a while now.

SELF-TEST: Assessment for Sleep Disorders (2 pages Saved)

[BROKEN LINK]

http://www.usc.edu/programs/cwfl/assets/pdf/sleep_test.pdf

University of Southern California - Sleep disorders self-test (full version)

 

2012 & 2015 – Sleep Without and With CloZAPine

LSF = Low Scores are Favorable | RT = Real Time | SW = Share (d) With



NA = Not Applicable | WC = With CloZAPine | WOC = Without CloZAPine


Discussion

SELF-TEST: Assessment for Sleep Disorders

>This is, another example of an assessment (USC) of which values are mapped into subscales.  In hindsight we have repeated bouts of insecurity.  During periods of vulnerability due to insecurity resting remains at the forefront dividing success from defeat.  Due to intentional habituation of near all niters at the university we nurtured a serious sleep disorder into existence.  After surviving a half of a dozen psychosocial challenges we cannot sleep without pharmaceuticals.  In 2012 our Insomnia issues were at ninety-four (94) percent. This was for the most part due to not being prescribed what we call our PharmNet2011 cocktail.  PharmNet2011 included at its’ core CloZAPine.

Extended Release Medications

>In 2015 we were back on PharmNet2011 (originally PharmNet2007) and our concerns with insomnia decreased substantially down to twenty-five (25) percent.  One of our priorities for 2016 was to get our doctor to put in writing that we require our keystone medication CloZAPine and that we have a history for responding poorly to extended release preparations such as Invega (PerOs or IM) for we require the cyclical benefits that medications in the PM afford.  The subject of rest and sleep will be discussed in more depth later for it is key to our continued health.

Cyclical Benefits of Medication

Cyclical medication: benefits beyond the typical dose: The concept of cyclical medication goes beyond the basic idea of taking a medicine regularly. It involves administering medication in a way that incorporates rhythms or cycles, aiming to maximize effectiveness and minimize side effects by leveraging the body's natural processes.

Steady State Medication - Steady State Pharmacodynamics

“In pharmacokinetics, steady state refers to the situation where the overall intake of a drug is fairly in dynamic equilibrium with its elimination. In practice, it is generally considered that steady state is reached when a time of 4 to 5 times the half-life for a drug after regular dosing is started.”

 

Associated with Treatment Preferences

Aside - Clearance (pharmacology) - Wikipedia

https://en.wikipedia.org/wiki/Clearance_(pharmacology)

In pharmacology, the clearance is a pharmacokinetic measurement of the volume of plasma from which a substance is completely removed per unit time; the usual units are mL/min. The quantity reflects the rate of drug elimination divided by plasma concentration.

Clearing Principle – Beta Argument

>It is wise that your doctor prescribes the right dosage of medication that daily it clears your system.  If it does not clear your system within say 23 hours the residual medication will build up and eventually reach toxic levels as measured by increased number and intensity of side effects / adverse reactions.  Example: Accumulation associated with increasing dizziness which in turn can increase the risk of falling.  Falls can be very serious.

Clearing per AI

The notion that medication must be completely eliminated from the body within 24 hours to prevent toxicity is a harmful misconception based on a misunderstanding of how drugs work. In reality, many medications are dosed specifically to reach a "steady state," where the amount of drug entering the body equals the amount being eliminated. This process ensures a consistent therapeutic effect over time and is not a sign of toxicity.

Why would you want a benzodiazepine to clear your system?

You might want benzodiazepines to clear from your system due to dependence, tolerance, severe withdrawal symptoms, or a need to pass drug tests for employment, child custody, or parole. A gradual tapering with medical supervision or a medically supervised detox program is the safest way to discontinue benzodiazepines, as abruptly stopping can cause dangerous or even life-threatening withdrawal symptoms like hallucinations, panic attacks, severe anxiety, and confusion.

 

FYI – Reference

Good Lesson on Pharmacokinetics

https://www.slideshare.net/PharmacologyEducationProject/elementary-pharmacokinetics-jap

Summary

FYI - Sleep Disorders and Tools for Assessment

National Institutes of Health (NIH) (.gov)

https://www.ncbi.nlm.nih.gov/books/NBK592970/

Primary sleep disorders, or disorders that occur in the sleep process itself, include insomnia, hypersomnolence, parasomnias, circadian rhythm sleep–wake disorders, and sleep-related movement and breathing disorders (Lane et al., 2022). Hypersomnolence—excessive daytime sleepiness—is often the result of the inability to sleep well at night, said Amita Sehgal. Parasomnias include disturbances during sleep, such as sleepwalking or sleep terrors, and can be debilitating. Sleep disorders may also be associated with metabolic and cardiovascular disorders as well as neurological and psychiatric disorders.